Abstract

Copper-Hydroxo Chelates of Clofibric Acid (CA): Reaction of Cu2+ with CA

2-(p-Chlorophenoxy)-2-Methylpropionic acid or (Clofibric acid (CA) chemical formula C10H11ClO3) is a ligand that binds to Peroxisome proliferator-activated receptorsalpha (PPARα). This ligand has two centers of attachments that can chelate a variety of metal ions. From our ongoing efforts to study the reaction of CA with many metal ions such as Al3+, Zn2+, Cr3+ and Fe3+, we are reporting the outcome of the reactions of CA with the hexa-aqua Cu2+ ion in aqueous solutions under ambient conditions using well established techniques. The main techniques used were potentiometry, UV-Vis, and IR spectroscopies. It appeared that the major species formed from the reaction of CA with Cu2+ is the ternary [Cu2+ (CA) (OH)2]- species. These studies are novel and shed light on this reaction system. UV-Vis spectra of CA, and CA-Cu2+ complexes are novel. IR spectroscopy proved the participation of the hydroxylate group of CA in the chelation of the Cu2+ ion.


Author(s):

Hamada YZ, Badr MZ and Darboe HA



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